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Please use this identifier to cite or link to this item: http://hdl.handle.net/123456789/488

Title: Evaluation of the Antimicrobial Properties of Gallic Acid at Alkaline pH
Authors: Barcelo, Jonathan
et al.
Keywords: genotoxicity, gallic acid, hydrophobicity, SOS gene expression, malondialdehyde-thiobarbituric acid adducts, oxidative stress, turbidimetry
Issue Date: 2014
Abstract: The antimicrobial propertyof gallic acid was investigated using DNA repair deficient Escherichia coli PQ37. Genotoxic concentrations of gallic acid were utilized against Escherichia coli ATCC 25922 cells to investigate its effects on cell surface hydrophobicity and bacterial growth in culture broth. The minimum genotoxic concentration of gallic acid against E. coli PQ37 was ≥0.031μmol*mL-1 although a higher concentration (≥0.50μmol*mL-1) was inhibitory and bactericidal to E. coli ATCC 25922 inturbidimetric assay. Cell surface hydrophobicity was decreased at a concentration of ≥0.63μmol*mL-1. The proposed mechanism of iron-gallic acid was oxidative stress based from the formation of malondialdehyde-thibarbituric acid adducts. Overall, the high minimum concentrations of iron-gallic acid are too high for enteric pharmaceutical applications, but can be used in other applications such as development of topical preparations, environmental inducers of oxidative stress or development of antimicrobial food packaging materials.
URI: http://hdl.handle.net/123456789/488
Appears in Collections:Unpublished Manuscripts

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